![]() This review aims to summarize the modulatory effects of cannabinoids on sleep physiology and provide a critical evaluation of the research on their potential therapeutic benefit in various sleep disorders.Ĭannabinoids Cannabis Hypnogram Insomnia Marijuana Narcolepsy Nightmares Parasomnia Restless leg syndrome Sleep Sleep apnea Sleep disordered breathing. org/about-narcolepsy/narcolepsy-fast-facts/. Clinical trials are underway for insomnia and obstructive sleep apnea management, but there remains a substantial need for rigorous large multi-center studies to assess the dose, efficacy, and safety of the various types of cannabinoids on sleep disorders. The hypnogram shows the sleep stages, respiratory events, oxygen saturation, sleep. a deficiency in the neurotransmitter has been identified as playing a role in narcolepsy. ![]() Although much of the pre-clinical and clinical data were derived from studies with relatively small sample sizes and limited by biases in assessment, and in clinical trials lack of allocation concealment, as a whole, the results indicate a potential therapeutic role for cannabinoids in the management of some sleep disorders. The hypnogram utilizes a Y axis and an X axis, displaying the sleep. The recent trend for legalization of medicinal cannabis and cannabinoid-containing products, together with their soporific effects, has led to a surge of interest of their potential therapeutic role in the management of some common sleep disorders, such as insomnia, sleep disordered breathing, and restless legs syndrome, and less common disorders such as narcolepsy and parasomnias. The hypnogram for the knockout mouse is characterized by the appearance of sleep-onset REM sleep episodes (arrowheads in Figure 4B, also see Figure 4C) and. ![]()
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